In This Blog
- Understand what 7-hydroxymitragynine (7-OH) is.
- How strong is 7-hydroxymitragynine in comparison to morphine?
- Learn the differences between 7-hydroxymitragynine and morphine.
- What are the different side effects, withdrawal, and safety concerns regarding these drugs?
There are various Addiction treatment programs located in the U.S.
One of the major questions that arises often is, “Is 7-hydroxymitragynine stronger than morphine?” This is one of the most critical questions as kratom products grow in popularity across the U.S. Even if the kratom leaves are marketed as natural remedies, their alkaloid 7-hydroxymitragynine (7-OH) is far more potent and carries major addiction. According to the National Institute on Drug Abuse (NIDA, 2024), 7-OH may be up to 13 times stronger than morphine, creating major concerns about dependence, overdose, and regulation.
What is 7-Hydroxymitragynine?
The kratom leaves contain the naturally occurring alkaloid 7-hydroxymitragynine (7-OH), which is usually less than 2% of total alkaloids. But in the concentrated extracts, it may go up to 98% (FDA, 2025). This increases its potency, which is why this drug has strong opioid-like actions and is highly abused.
Is 7-Hydroxymitragynine More Powerful than Morphine?
Yes. It is scientifically proven that 7-hydroxymitragynine connects with the opioid receptors more than morphine (NIH, 2024). Morphine on the one hand is highly controlled and prescribed by a physician to treat pain, but 7-OH on the other hand is uncontrollable, has not been approved and is linked with unpredictable risks.
7-Hydroxymitragynine vs Morphine
Feature | 7-Hydroxymitragynine (7-OH) | Morphine |
Potency | Up to 13x stronger (NIDA, 2024) | Standard opioid analgesic strength |
Medical Use | None, not FDA-approved | Pain management, anesthesia |
Addiction Risk | High, rapid dependence | High, but clinically monitored |
Regulation | Unregulated, mislabeled products | Schedule II controlled substance |
Side Effects | Withdrawal, seizures, respiratory depression | Respiratory depression, constipation, and dependence |
Is 7-Hydroxymitragynine the Same as Kratom?
No, as the Kratom is the leaf of Mitragyna speciosa, which has not been cooked. It is also composed of several alkaloids, with mitragynine as the biggest constituent and 7-OH in small quantities (CDC, 2024). However, concentrated 7-OH extracts are much stronger than the conventional kratom leaf products.
7-Hydroxymitragynine Extract
Extracts containing high levels of 7-OH can be found in concentrated extracts that are sold as powders, gummies, or capsules. These are unlabeled and unregulated products, whereby potency may not be predictable (FDA, 2025).
Is 7-Hydroxymitragynine Addictive?
Yes, it is considered an addictive substance. This is because of its high potency at mu-opioid receptors. The dependence on the substance develops faster when compared to kratom leaf, and the withdrawal symptoms are just like opioid withdrawal (NIH, 2024).
Is 7-Hydroxymitragynine Legal?
7-OH is not approved by the FDA, and this is a drug of concern according to the DEA 2024 reports. There are many states where kratom is federally legal, but many U.S. states have definitely banned the use of kratom and concentrated 7-OH products because of the safety risks.
Is 7-Hydroxymitragynine Safe?
According to FDA 2025, this drug is not safe. The reputed institution warns that the consumption of concentrates can cause many health issues, which include seizures, confusion, respiratory problems, or even death. The safety claims from various vendors are misleading and vague, as none of the medical bodies have approved the consumption of 7-OH as safe.
What are the Side Effects of 7-Hydroxymitragynine?
Various side effects pose serious health issues. Here are some of them listed below.
- Person might witness nausea and vomiting
- Increased heartbeat and high blood pressure
- Sweating and agitation
- Confusion and dizziness
- Severe withdrawal symptoms (CDC, 2024)
What Does the Withdrawal from 7-Hydroxymitragynine Look Like?
The withdrawal symptoms from this drug look like the following:
- The addict might suffer from muscle pain, nausea and insomnia
- They might also feel mental health issues such as anxiety, depress an irritability
- The craving for the drug kicks in higher, and there is an increased risk of relapse.
According to NIDA 2024, these symptoms last longer in comparison to standard kratom and somewhat resemble the symptoms of opioid withdrawal.
What is the Treatment for 7-Hydroxymitragynine Addiction?
There are many treatments available to cure this addiction:
- Professionals might suggest medical detox so that withdrawal can be managed safely.
- There is Cognitive Behavioral Therapy that helps control cravings and increases coping.
- When it is appropriate, there are medication-assisted treatments.
- There are support groups that help in controlling the relapse.
Pro Tip from Doctor: It is not a wise decision to attempt a detox from 7-OH alone or without any professional help, as this increases the risk of relapse. So, it is better to seek professional help to ensure safety.
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Why is it Important to Seek Professional Care?
When a person is addicted to 7-Hydroxymitragynine, things can escalate very quickly. That is why professional care is important, as it provides:
- Medical supervision all around the clock.
- Management of symptoms and prevention of relapse.
- Recovery programs that are structured.
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Contact Palm Coast Treatment Solutions to Get Help in Combating 7-Hydroxymitragynine Addiction
If you or someone you love is battling through 7-hydroxymitragynine addiction, then you need to take action now. With the help of Palm Coast Treatment Solutions, you can defeat the addiction easily, as we offer:
- Treatment plans that are personalized and customized according to the addiction levels and symptoms.
- Medical detox is quite safe and offered with supervision all around the clock.
- Therapy and aftercare that will help in long-term recovery.
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No matter what you’re going through, you’re not alone. Our dedicated team is here to provide a safe, judgment-free space where you can talk openly and honestly. Whether you need emotional support, resources, or just someone to listen.
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Key Takeaways
- According to NIDA 2024, 7-hydroxymitragynine is 13x stronger than morphine.
- The drug is not approved by the FDA and has major addiction risks.
- The extracts of this drug are quite unregulated and unsafe.
- Withdrawal is severe and resembles opioid withdrawal.
The safest recovery option from this addiction is with the help of professional treatment.
FAQs
Is 7-hydroxymitragynine stronger than morphine?
The answer is yes. This is because the studies suggest that 7-OH can be upto 13 times stronger in comparison to morphine (NIDA, 2024). However, this drug is not FDA-approved like morphine. When there is a lack of medical oversight, the use of this drug can lead to many problems.
How strong is 7-hydroxymitragynine when taken for pain?
7-OH shows analgesic effects much stronger than morphine. While the drug might relieve pain, the continuous usage can increase the tolerance, dependence and risks of overdose. No medical authority has approved it for safe pain management.
Exactly what percent of kratom is 7-hydroxymitragynine
When we talk about natural kratom leaves, they usually have less than 2% 7-OH. However, many extracts also reach up to 98% according to FDA, 2025. This difference in the concentration levels show why it is so dangerous to consume this drug.
Is 7-hydroxymitragynine known to increase dopamine levels?
Yes the drug is known to increase the dopamine levels just like opioids. This reinforces reward and habit formation. That is why the usage of this drug becomes addictive, and the cycle of cravings increases.
Is 7-hydroxymitragynine addictive?
Yes it is very addictive. The drug works on opioid receptors, and it increases the dependency quite quickly and shows strong withdrawal symptoms, according to NIH, 2024 reports. The constant users have shown signs of cravings, anxiety and physical discomfort when they tried to quit the drug.
How long does a 7-OH high last?
When we talk about a typical 7-OH high, it can easily last for several hours. The duration lasts on the basis of the dosage taken and the form. When concentrated extracts are consumed, they may prolong the duration. However, they also heighten the risk of overdose and show severe withdrawal symptoms.
Is kratom as strong as morphine?
When we talk about kratom leafit is quite weaker in comparison to morphine. However, when it comes to 7-OH alkaloid, this form becomes much stronger than morphine in its concentrated form. This difference shows the high risks of extracts compared to natural kratom.
