A natural alkaloid chemical, 7-hydroxymitragynine, is found in the kratom leaves. It is not very high, yet it is a significant constituent of the psychoactive effects of kratom. People are resorting to kratom products in large numbers to treat pain, anxiety, or opioid withdrawal symptoms but 7-OH is as harmful as it can be, including being addictive.
The knowledge of the impact of 7-hydroxymitragynine is important in order to make informed and secure choices and such information is particularly important to those, who think of using kratom as a supplement or some sort of relaxation support.
What is 7OH?
The substance 7-hydroxymitragynine (7OH) is a ketone (phenylpropionic) kratom plant (Mitragyna speciosa) derivative. Since kratom possesses an extensive number of alkaloids, 7OH is believed to be one of the strongest alkaloids whereby, it can be regarded as a partial agonist of the mu-opioid receptors within the brain.
It implies that it can cause the same effects as opioids, including analgesia, euphoria and relaxation, but tolerance and dependence are associated with it. The 7OH concentration of raw kratom is not very high but metabolically active and plays a major part in the overall outcome of kratom in respect to the strength of kratom.
How Long Does 7OH Last?
The period of action of 7-hydroxymitragynine is approximately 4-6 hours and this depends on the dose, body weight and tolerance level. Smaller doses give the users stimulation or mood elevation and larger amounts unite them and relieve pain.
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How Long Does 7OH Stay in Your System?
Similar to the majority of psychoactive drugs, the 7-hydroxymitragynine detection period relies on both the rate of metabolism of a particular test subject and usual use. On average:
Blood: 24 hours can be detected.
Urine: It may be permanent for up to 3-7 days depending on the dosage and frequency of use.
Hair: May take as long as 90 days.
This is where the inconsistency comes in; that is why it is important to educate the users about the fact that the metabolites of kratom, such as 7OH may be found in the special drug tests.
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Is 7-hydroxymitragynine Stronger than Morphine?
It has also been implied that 7-hydroxymitragynine may be a few times better than morphine in its affinity toward opioid receptors. Although this does not state explicitly that it is more effective at the average doses of kratom, it is the reason why 7OH has become an issue of concern among healthcare professionals.
This is also among the reasons why this power can be abused and addictive. Similarly to opioids, 7OH may induce a tolerance/withdrawal cycle that is dangerous in a substance use disorder victim.
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How Long Does it Take for 7-hydroxymitragynine to Kick In?
The effects of 7-hydroxymitragynine may begin 15 to30 minutes after administration depending on the route of administration (powder, capsule, or extract). Peak effects take between 1 and 2 hours.
What Does 7-hydroxymitragynine Do to Your Body?
When taken in its form, the 7-hydroxymitragynine is active and it attaches to the opioid receptors in the nervous system and the brain. Its effects can include:
- Pain relief
- Sedation and relaxation
- Euphoria or mood elevation.
- Reduced anxiety
- Physical long-term dependence.
There are side effects like nausea, constipation, drowsiness and dizziness, particularly at higher doses. Dependency and withdrawal symptoms are possible, particularly when it is used long/heavily.
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What are the Effects of 7-hydroxymitragynine?
The activity of 7-hydroxymitragynine may be dependent on the dose, tolerance and personal biology. The most frequent reports of effects are:
Positive effects:
- Analgesia (pain relief)
- Decreased anxiety
- Mild euphoria
- Relaxation and calmness
- Negative effects:
- Constipation
- Nausea or vomiting
- Fatigue and sedation
- Risk of addiction and withdrawal.
With chronic use, liver strain may be possible.
Although a few of them self-treat with kratom in order to manage their pain or mental conditions, the risk of addiction to 7-OH makes self-treatment risky.
Treatment for 7-hydroxymitragynine Misuse
You may have to seek professional help in case you or a loved one is experiencing the 7-hydroxymitragynine dependency. Because 7OH is binding to the opioid receptors of the brain, the withdrawal symptoms, such as irritability, insomnia, aches, and cravings, can be encountered as a result of not withdrawing gradually.
Good remedies can consist of:
- Medical Detox: The withdrawal effects treatment.
- Addiction Treatment Programs: It is an addiction treatment that is structured in either an inpatient or outpatient treatment that involves treatment therapy, support group work and relapse prevention.
- Mental Health Treatment: The use of kratom predisposes the development of mental illnesses like anxiety or depression, which are treated.
- Whole Person Approaches: Mindfulness, nutrition and exercise to make recovery.
Palm Coast Treatment Solutions has a wide range of programs which may assist those who have become dependent on kratom and other substances to get back on their feet.
Get to know more about our addiction and mental health treatment programs; call us at (386) 284-4151 today.
Overcome Addiction with Palm Coast Treatment Solutions.
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Conclusion
One of the strong chemicals in kratom, which have been reported to be therapeutic and harmful is 7-hydroxymitragynine. Although it can relieve certain pain and simultaneously calm down, an opioid-like effect subjects a person to addiction and withdrawal. Being aware of the consequences, the time and the risk may make you make more secure decisions.
In order not to turn the misuse into a problem, it is always possible to start the path towards recovery by addressing a professional.
FAQs About 7-hydroxymitragynine
1. Will 7-hydroxymitragynine make you fail a drug test?
The common drug tests normally fail to detect 7-hydroxymitragynine, but special screening analysis of kratom alkaloids can be done. The employers or the legal agencies can also request advanced testing and so there is always a possibility of detection when it comes to the type of test applied.
2. How long does a kratom high last?
The average duration of a kratom high is 4-6 hours of 7-hydroxymitragynine. With a larger dosage or greater effects, the effects are longer lasting and deeper, since a dosage can be longer based on the tolerance and the route.
3. Will hydroxyzine cause a positive drug test?
Hydroxyzine is a type of antihistamine and it does not usually test positive. However, cross-reactivity may also result in false positives in rare cases hence confirmation lab tests are commonly required to rule out the possibility of false identification.
4. How much 7-hydroxymitragynine is in kratom powder?
Natural powder kratom contains highly dilute concentrations of 7-hydroxymitragynine, which is usually less than 2 percent of the total alkaloid concentration. Even though it is in low amounts, it leads to a substantial contribution to the general and opioid-like effects of kratom in the human body.
5. Does 7-hydroxymitragynine increase dopamine?
Yes, 7-hydroxymitragynine is an opioid receptor antagonist and indirectly increases the level of dopamine in the brain. It helps in triggering some state of euphoria, motivation and an enjoyable feeling, but on the other hand, it also causes dependence and addiction among those who are likely to use it on a regular or excessive basis.
